If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

The belief that primitive men lived like beasts and that civilisation developed out of these brutal origins is found in numerous ancient authors, both Greek and Latin. It forms part of certain theories about the beginnings of culture current in late antiquity. These are notoriously difficult to trace to their sources, but they already existed in some form in the fifth century b.c. One idea common to these theories is that of progress, and for this reason a fragment of Xenophanes (...) is sometimes cited as their remote prototype: ‘The gods did not reveal all things to men from the beginning; instead, by seeking, men discover what is better in time’. Mainly on the strength of this fragment, Ludwig Edelstein devoted the first chapter of his book The Idea of Progress in Classical Antiquity to Xenophanes, and W. K. C. Guthrie has even declared that there is good reason to attribute to him a fuller account of progress, one that would include details found in later authors who speak of the early life of mankind. One of these details is the statement that the life of primitive men was ‘brutal’ or ‘beastlike’ . In these authors the implication of that term varies from ‘unschooled in the basic crafts’ to ‘inhumanly violent and bloodthirsty’. In one sense or the other it is repeatedly encountered in ancient references to this subject. Accounts of primitive brutishness which make use of the word θηριώδης (or θηριωδς can be found in the Suppliants of Euripides, in the Hippocratic treatise On Ancient Medicine, in three passages of Diodorus, one of which is thought by some to contain Democritean doctrine, in four passages of Isocrates, in a fragment from a satyr-play Sisyphus which the ancient sources attribute variously to Euripides and to Critias, in a fragment of Athenion, in a second-century inscription, in Plutarch, in Tatian, in Themistius, and in a scholion to Euripides. (shrink)

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

The volume presents essays on the philosophical explanation of the relationship between body and soul in antiquity from the Presocratics to Galen. The title of the volume alludes to a phrase found in Plato, Aristotle and Plotinus, referring to aspects of living behaviour involving both body and soul, and is a commonplace in ancient philosophy, dealt with in very different ways by different authors.

Doctors have an ethical and legal duty to respect patient confidentiality. We consider the basis for this duty, looking particularly at the meaning and value of autonomy in health care. Enabling patients to decide how information about them is disclosed is an important element in autonomy and helps patients engage as active partners in their care.Good quality data is, however, essential for research, education, public health monitoring, and for many other activities essential to provision of health care. We discuss whether (...) it is necessary to choose between individual rights and the wider public interest and conclude that this should only rarely be necessary. The paper makes some recommendations on practical steps which could help ensure that good quality information is available for work which benefits society and the public health, while still enabling patients’ autonomy to be respected. (shrink)

This book is an in-depth treatment of Darwinian evolutionism and its applicability to the investigation of the archaeological record. The authors explain the unique position that this kind of evolutionism holds in science and how it bears on any attempt to explain change over time in the organic world, demonstrate commonalities between archaeology and paleobiology, and explain the principles, methods, and techniques - the systematics - inherent in the approach.

The author proposes an analysis of boredom. The analysis he proposes is that boredom is an unpleasant mental state consisting of weariness, restlessness, and lack of interest, where certain causal relations exist among the components. He goes on to elaborate on and defend his analysis, concluding with some thoughts on the idea that boredom has some grand metaphysical significance.

Archaeologists have proposed that behavioral knowledge of a tool can be conceptualized as a “recipe”—a unit of cultural transmission that combines the preparation of raw materials, construction, and use of the tool, and contingency plans for repair and maintenance. This parallels theories in cognitive psychology that behavioral knowledge is hierarchically structured—sequences of actions are divided into higher level, partially independent subunits. Here we use an agent-based simulation model to explore the costs and benefits of hierarchical learning relative to holistic learning, (...) where entire behavioral sequences are learned in an all-or-nothing fashion, and diffusionist learning, where actions are completely independent. Hierarchical learning is favored under the reasonable assumptions that learning is associated with some degree of both error and cost, and that behavior can be grouped into subunits that repeat in one or more tool recipes. These general predictions can be tested in the archaeological and ethnographic record. Recent advances in evolutionary developmental biology have revealed a number of parallels between the hierarchically structured, recipe-like organization of behavioral knowledge that we examine here and the manner in which biological organisms develop. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Political Theology of Climate Change by Michael S. Northcott, and: Restored to Earth: Christianity, Environmental Ethics, and Ecological Restoration by Gretel Van WierenKevin J. O’BrienA Political Theology of Climate Change Michael S. Northcott grand rapids, mi: eerdmans, 2013. 335 pp. $30.00Restored to Earth: Christianity, Environmental Ethics, and Ecological Restoration Gretel Van Wieren washington, dc: georgetown university press, 2013. 208 pp. $29.95These two excellent books, A Political Theology (...) of Climate Change by Michael S. Northcott and Restored to Earth by Gretel Van Wieren, offer distinct directions for Christian environmental ethics: Northcott develops a rigorous analysis of climate change as a failure of enlightenment rationality and politics, while Van Wieren argues that those who care about the earth can connect with it through the practice of ecological restoration. Northcott theologically defines a complex global problem; Van Wieren theologically engages a community-based solution. Each book advances Christian environmental ethics in important ways; considered together, they have much to teach about the content and methods of the field.Northcott’s A Political Theology of Climate Change argues that climate change is a “cosmopolitical crisis” and that Christians should embrace a more ecological and theological politics in response. Theologians and ethicists have long argued that environmental degradation has cosmological roots: The belief that human beings are separate from nature makes global-scale degradation and pollution acceptable. Northcott adds a nuanced political analysis, noting that modern politics is based on a denial “that the weather is political, or that politics influences the climate” (46). Enlightenment thinkers who laid the groundwork for contemporary political structures insisted that storms and floods were not divine responses to human behavior, so modern nation-states are premised on an ideological separation from nature. Climate change reveals the failure of such thinking, so the facts of climate change pose an inherently political challenge.Thus, failures to act on climate change are political failures. Mainstream politics cannot consider that economic growth is unsustainable because it is premised on ignorance about nature. Nations cannot collaborate to solve the problem because they have no common moral agreement “about the ends and goals of human life” (245). Any response to climate change that simply extends [End Page 198] the enlightenment project—by ascribing “rights” to the natural world, or by trusting existing secular political structures—is doomed to failure. Instead, climate change calls for a different cosmology and a different politics.Northcott argues that both can be found in the Christian tradition. Natural law thinking respects the relationship between human beings and external moral standards “set into the structure of the cosmos,” demanding careful accounting for the atmospheric consequences of human action (246). Virtue ethics teaches the ideal of politics as a “community of friendship and love,” nurturing practices of participation in the good life, lived with less consumption and less destructive energy (200).Northcott hopes that small-scale communities inspired by Christian cosmology and Christian politics will transition away from destructive practices and thereby demonstrate a new way of life to the world. His book concludes by reasserting that because climate change is a political problem, it is fundamentally a theological problem, calling human communities to “re-create the historic and customary connections between nature and culture, land and life, love for neighbour and nature which are central to the Jewish and Christian messianism of empire-challenging love” (316).In contrast to Northcott’s focus on political and philosophical failures, Gretel Van Wieren’s Restored to Earth seeks a “more positive, solution-oriented” approach to Christian ethics (viii). The book is about reconnecting humans with the natural world through ecological restoration, “the science and art of repairing ecosystems that have been damaged by human activities” (2), and it argues that restoration models moral life by creating physical, intellectual, emotional, communal, and spiritual connections with the natural world.Van Wieren begins with an interdisciplinary definition of ecological restoration and argues that views on the practice depend upon varied definitions of nature. She then moves to a nuanced account of restoration ecology as a spiritual practice (chapter 3) of community formation (chapter 4). Evocatively recounting a controlled prairie burn in Illinois on Maundy Thursday, Van Wieren... (shrink)

While new generations of implantable brain computer interface devices are being developed, evidence in the literature about their impact on the patient experience is lagging. In this article, we address this knowledge gap by analysing data from the first-in-human clinical trial to study patients with implanted BCI advisory devices. We explored perceptions of self-change across six patients who volunteered to be implanted with artificially intelligent BCI devices. We used qualitative methodological tools grounded in phenomenology to conduct in-depth, semi-structured interviews. Results (...) show that, on the one hand, BCIs can positively increase a sense of the self and control; on the other hand, they can induce radical distress, feelings of loss of control, and a rupture of patient identity. We conclude by offering suggestions for the proactive creation of preparedness protocols specific to intelligent—predictive and advisory—BCI technologies essential to prevent potential iatrogenic harms. (shrink)

The essays in this volume explore current work in central areas of philosophy, work unified by attention to salient questions of human action and human agency. They ask what it is for humans to act knowledgeably, to use language, to be friends, to act heroically, to be mortally fortunate, and to produce as well as to appreciate art. The volume is dedicated to J. O. Urmson, in recognition of his inspirational contributions to these areas. All the essays but one have (...) been specially written for this volume. (shrink)

The project of the paper is a critical examination of the "strong thesis of eliminative materialism" in the philosophy of mind--The claim that all the mental entities that constitute the framework of commonsense psychology are, In principle at least, Eliminable from our ontology. The central conclusion reached is that the traditional formulation of this thesis is demonstrably untenable as it rests on a mistaken view of the relationship between our psychological self-Knowledge and language.

The plot of Iphigenia in Tauris is usually thought to be Euripides' own invention. Its basic assumption can be found in Proclus' summary of the Cypria, viz. that a deer was substituted for Iphigenia during the sacrifice at Aulis and that she herself was removed to the land of the Tauri. Her later rescue by Orestes and Pylades, however, cannot be traced with probability to any work of art or literature earlier than Euripides' play. In this play, in which Orestes (...) recognizes and then saves the sister whom he had long thought dead, it is assumed that her replacement by a deer went unseen by those present at the sacrifice. The sequel which this assumption allowed Euripides to invent is original only in a limited sense, since it bears the imprint of several familiar story types. These types include the following: the murder of a kinsman is narrowly averted by a recognition; a reunion is followed by an intrigue; and a maiden is rescued. Each is used elsewhere by Euripides. The first two, for example, are found in Cresphontes, the second in Electra, and the third in Andromeda. Correspondences of this sort, based on plot patterns, will naturally gain in interest if it can be shown that they throw light on a play's meaning or on the process that led to its creation. The student of dramatic plots, however, soon discovers that analogies between them are easy to draw and can be quickly multiplied. (shrink)

We agree that the emergence of cumulative technological culture was tied to nonsocial cognitive skills, namely, technical-reasoning skills, which allowed humans to constantly acquire and improve information. Our concern is with a reading of the history of cumulative technological culture that is based largely on modern experiments in simulated settings and less on phenomena crucial to the long-term dynamics of cultural evolution.

White climate ethicists have a responsibility to learn, teach, and write about the intersections between climate change and white supremacy. Learning from Andrea Smith’s understanding of white supremacy as three pillars—commodification, orientalism, and genocide—built from heteropatriarchy, this essay argues that white climate ethicists should focus on particular experiences rather than universal narratives; learn from histories of colonization, slavery, and genocide; and support coalitions that empower people of color and indigenous communities. A focus on the writings of scholars from marginalized identities (...) leads to an understanding of climate change as atmospheric defilement. (shrink)

The essays in this volume explore current work in central areas of philosophy, work unified by attention to salient questions of human action and human agency. They ask what it is for humans to act knowledgeably, to use language, to be friends, to act heroically, to be mortally fortunate, and to produce as well as to appreciate art. The volume is dedicated to J. O. Urmson, in recognition of his inspirational contributions to these areas. All the essays but one have (...) been specially written for this volume. (shrink)